Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition

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Item Type:	Article
Title:	Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition
Creators Name:	Aleksandrova, K., Pischon, T., Buijsse, B., May, A.M., Peeters, P.H., Bueno-de-Mesquita, H.B., Jenab, M., Fedirko, V., Dahm, C.C., Siersema, P.D., Freisling, H., Ferrari, P., Overvad, K., Tjønneland, A., Trichopoulou, A., Lagiou, P., Naska, A., Pala, V., Mattiello, A., Ohlsson, B., Jirström, K., Key, T.J., Khaw, K.T., Riboli, E. and Boeing, H.
Abstract:	AIM: Weight change during adult life may reflect metabolic changes and influence colorectal cancer (CRC) development, but such role is not well established. We aimed to explore the association between adult weight change (from age 20 to 50) and CRC risk. In particular, we investigated differences according to colon and rectal cancer, sex and measures of attained adiposity. METHODS: We included 201,696 participants from six participating countries in the European Prospective Investigation into Cancer and Nutrition (1992-2010). During a mean follow-up of 11.2 years 2384 (1194 in men and 1190 in women) incident CRC cases occurred. Cox proportional hazard models adjusted for body mass index at age 20 and lifestyle factors at study recruitment were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: After multivariable adjustment, each kg of weight gained annually from age 20 to 50 was associated with a 60% higher risk of colon cancer (95% CI 1.20-2.09), but not rectal cancer (HR 1.13, 95% CI 0.79-1.62, Pinteraction=0.04). The higher risk of colon cancer was restricted to people with high attained waist circumference at age 50 (HR 1.82, 95%CI 1.14-2.91, Pinteraction=0.02). Results were not different in men and women (Pinteraction=0.81). CONCLUSION(S): Adult weight gain, as reflected by attained abdominal obesity at age 50, increases colon cancer risk in both men and women. These data underline the importance of weight management and metabolic health maintenance in early adult life years for colon cancer prevention.
Keywords:	Body Weight Change, Colorectal Neoplasms, Abdominal Obesity, Cancer Prevention
Source:	European Journal of Cancer
ISSN:	0959-8049
Publisher:	Elsevier
Volume:	49
Number:	16
Page Range:	3526-3536
Date:	November 2013
Official Publication:	https://doi.org/10.1016/j.ejca.2013.06.021
PubMed:	View item in PubMed

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