Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia

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Item Type:	Review
Title:	Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia
Creators Name:	Regalo, G. and Leutz, A.
Abstract:	Initiating neoplastic cell transformation events are of paramount importance for the comprehension of regeneration and vanguard oncogenic processes but are difficult to characterize and frequently clinically overlooked. In epithelia, pre-neoplastic transformation stages are often distinguished by the appearance of phenotypic features of another differentiated tissue, termed metaplasia. In haemato/lymphopoietic malignancies, cell lineage ambiguity is increasingly recorded. Both, metaplasia and biphenotypic leukaemia/lymphoma represent examples of dysregulated cell differentiation that reflect a history of trans-differentiation and/or epigenetic reprogramming. Here we compare the similarity between molecular events of experimental cell trans-differentiation as an emerging therapeutic concept, with lineage confusion, as in metaplasia and dysplasia forecasting tumour development.
Keywords:	Carcinogenesis, Haematopoiesis, Metaplasia, Transcription Factor, Trans-Differentiation, Animals, Mice
Source:	EMBO Molecular Medicine
ISSN:	1757-4676
Publisher:	EMBO Press / Wiley
Volume:	5
Number:	8
Page Range:	1154-1164
Date:	August 2013
Official Publication:	https://doi.org/10.1002/emmm.201302834
PubMed:	View item in PubMed

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