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| Item Type: | Review |
|---|---|
| Title: | Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia |
| Creators Name: | Regalo, G. and Leutz, A. |
| Abstract: | Initiating neoplastic cell transformation events are of paramount importance for the comprehension of regeneration and vanguard oncogenic processes but are difficult to characterize and frequently clinically overlooked. In epithelia, pre-neoplastic transformation stages are often distinguished by the appearance of phenotypic features of another differentiated tissue, termed metaplasia. In haemato/lymphopoietic malignancies, cell lineage ambiguity is increasingly recorded. Both, metaplasia and biphenotypic leukaemia/lymphoma represent examples of dysregulated cell differentiation that reflect a history of trans-differentiation and/or epigenetic reprogramming. Here we compare the similarity between molecular events of experimental cell trans-differentiation as an emerging therapeutic concept, with lineage confusion, as in metaplasia and dysplasia forecasting tumour development. |
| Keywords: | Carcinogenesis, Haematopoiesis, Metaplasia, Transcription Factor, Trans-Differentiation, Animals, Mice |
| Source: | EMBO Molecular Medicine |
| ISSN: | 1757-4676 |
| Publisher: | EMBO Press / Wiley |
| Volume: | 5 |
| Number: | 8 |
| Page Range: | 1154-1164 |
| Date: | August 2013 |
| Official Publication: | https://doi.org/10.1002/emmm.201302834 |
| PubMed: | View item in PubMed |
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