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| Item Type: | Article |
|---|---|
| Title: | Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis |
| Creators Name: | Shalapour, S., Deiser, K., Kuehl, A.A., Glauben, R., Krug, S.M., Fischer, A., Sercan, O., Chappaz, S., Bereswill, S., Heimesaat, M.M., Loddenkemper, C., Fromm, M., Finke, D., Haemmerling, G.J., Arnold, B., Siegmund, B. and Schueler, T. |
| Abstract: | Interleukin-7 (IL-7) is a major survival factor for mature T cells. Therefore, the degree of IL-7 availability determines the size of the peripheral T cell pool and regulates T cell homeostasis. Here we provide evidence that IL-7 also regulates the homeostasis of intestinal epithelial cells (IEC), colon function and the composition of the commensal microflora. In the colon of T cell-deficient, lymphopenic mice, IL-7-producing IEC accumulate. IEC hyperplasia can be blocked by IL-7-consuming T cells or the inactivation of the IL-7/IL-7R signaling pathway. However, the blockade of the IL-7/IL-7R signaling pathway renders T cell-deficient mice more sensitive to chemically-induced IEC damage and subsequent colitis. In summary, our data demonstrate that IL-7 promotes IEC hyperplasia under lymphopenic conditions. Under non-lymphopenic conditions, however, T cells consume IL-7 thereby limiting IEC expansion and survival. Hence, the degree of IL-7 availability regulates both, T cell and IEC homeostasis. |
| Keywords: | CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Colitis, Epithelial Cells, Homeostasis, Hyperplasia, Interleukin-7, Interleukin-7 Receptors, Intestines, Phenotype, RAG-1 Genes, Signal Transduction, T-Lymphocytes, Animals, Mice |
| Source: | PLoS ONE |
| ISSN: | 1932-6203 |
| Publisher: | Public Library of Science |
| Volume: | 7 |
| Number: | 2 |
| Page Range: | e31939 |
| Date: | 27 February 2012 |
| Official Publication: | https://doi.org/10.1371/journal.pone.0031939 |
| PubMed: | View item in PubMed |
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