ACE2, angiotensin-(1-7), and Mas: the other side of the coin

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Item Type:	Review
Title:	ACE2, angiotensin-(1-7), and Mas: the other side of the coin
Creators Name:	Bader, M.
Abstract:	The renin–angiotensin system (RAS) has recently been extended by the addition of a novel axis consisting of the angiotensin-converting enzyme 2 (ACE2), the heptapeptide angiotensin (1–7) (Ang-(1–7)), and the G protein-coupled receptor Mas. ACE2 converts the vasoconstrictive and pro-oxidative peptide angiotensin II (Ang II) into Ang-(1–7) which exerts vasodilatory and antioxidative effects via its receptor Mas. Thereby, ACE2 regulates the local actions of the RAS in cardiovascular tissues and the ACE2/Ang-(1–7)/Mas axis exerts protective actions in hypertension, diabetes, and other cardiovascular disorders. Consequently, this novel RAS axis represents a promising therapeutic target for cardiovascular and metabolic diseases. This article is published as part of the special issue on the Renin-Angiotensin System.
Keywords:	Angiotensin I, Angiotensin III, Brain, G-Protein-Coupled Receptors, Gene Expression, Kidney, Lung, Myocardium, Peptide Fragments, Peptidyl-Dipeptidase A, Proto-Oncogene Proteins, Renin-Angiotensin System, Animals
Source:	Pfluegers Archiv European Journal of Physiology
ISSN:	0031-6768
Publisher:	Springer
Volume:	465
Number:	1
Page Range:	79-85
Date:	January 2013
Official Publication:	https://doi.org/10.1007/s00424-012-1120-0
PubMed:	View item in PubMed

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