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| Item Type: | Article |
|---|---|
| Title: | Deciphering a global network of functionally associated post-translational modifications |
| Creators Name: | Minguez, P., Parca, L., Diella, F., Mende, D.R., Kumar, R., Helmer-Citterich, M., Gavin, A.C., van Noort, V. and Bork, P. |
| Abstract: | Various post-translational modifications (PTMs) fine-tune the functions of almost all eukaryotic proteins, and co-regulation of different types of PTMs has been shown within and between a number of proteins. Aiming at a more global view of the interplay between PTM types, we collected modifications for 13 frequent PTM types in 8 eukaryotes, compared their speed of evolution and developed a method for measuring PTM co-evolution within proteins based on the co-occurrence of sites across eukaryotes. As many sites are still to be discovered, this is a considerable underestimate, yet, assuming that most co-evolving PTMs are functionally associated, we found that PTM types are vastly interconnected, forming a global network that comprise in human alone >50,000 residues in about 6000 proteins. We predict substantial PTM type interplay in secreted and membrane-associated proteins and in the context of particular protein domains and short-linear motifs. The global network of co-evolving PTM types implies a complex and intertwined post-translational regulation landscape that is likely to regulate multiple functional states of many if not all eukaryotic proteins. |
| Keywords: | Post-Translational Modifications, Protein Regulation, Proteomics, PTM Code, PTM Crosstalk |
| Source: | Molecular Systems Biology |
| ISSN: | 1744-4292 |
| Publisher: | Nature Publishing Group |
| Volume: | 8 |
| Page Range: | 599 |
| Date: | 17 July 2012 |
| Official Publication: | https://doi.org/10.1038/msb.2012.31 |
| PubMed: | View item in PubMed |
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