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| Item Type: | Article |
|---|---|
| Title: | Activating autoantibodies against the AT1-receptor in vascular disease |
| Creators: |
Dechend, R.  ORCID: https://orcid.org/0000-0001-6636-3080, Dragun, D., Herse, F. ORCID: https://orcid.org/0000-0002-9305-8134, Riemekasten, G., Schulze-Forster, K., Mueller, D.N. ORCID: https://orcid.org/0000-0003-3650-5644 and Heidecke, H.
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| Abstract: | Activating autoantibodies to the angiotensin II type I receptor (AT1-AA) have been described in different vascular diseases: preeclampsia, non HLA-mediated transplantat rejection and systemic sclerosis. All three diseases are characterised by severe obliterative, inflammatory vasculopathy with a prominent autoimmune background. AT1-AA were described 12 years ago in preeclampsia. Preeclampsia is a common, pregnancy- induced disorder, consisting of hypertension and proteinuria in the last trimester. The condition is one of the leading causes for maternal and perinatal morbidity and mortality. An observation of a patient with transplant rejection without HLA antibodies and a preeclampsia in her medical history, let to the discovery of AT1-AA in these patients. Until then we relied on a subjective, time consuming bioassay to detect AT1-AA. The establishment and validation of a cell-based ELISA facilitated research on AT1-AA immensely. Recently, AT1-AA were found in patients with systemic sclerosis. |
| Keywords: | AT1-Receptor, AT1-AA, Preeclampsia, Transplant Rejection, Systemic Sclerosis |
| Source: | Transplantationsmedizin |
| ISSN: | 0946-9648 |
| Publisher: | Pabst Science Publishers |
| Volume: | 24 |
| Number: | 1 |
| Page Range: | 20-26 |
| Date: | 2012 |
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