Recurrent rectal cancer: diagnosis with dynamic MR imaging

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Item Type:	Article
Title:	Recurrent rectal cancer: diagnosis with dynamic MR imaging
Creators Name:	Mueller-Schimpfle, M., Brix, G., Layer, G., Schlag, P.M., Engenhart, R., Frohmuller, S., Hess, T., Zuna, I., Semmler, W. and van Kaick, G.
Abstract:	PURPOSE: To evaluate whether dynamic magnetic resonance (MR) imaging can increase the diagnostic accuracy in suspected local recurrence of rectal carcinoma. MATERIALS AND METHODS: Eighteen patients (seven men, 11 women, aged 26-78 years) with 19 suspect lesions were examined. T1-weighted (pre- and postcontrast) and T2-weighted spin-echo images were read by three observers. Computed tissue-specific enhancement parameters were obtained and displayed on gray-scale images (pharmacokinetic mapping). RESULTS: Reading of the spin-echo images yielded a sensitivity of 91%-100% (confidence interval, 67%, 100%), a specificity of 29%-43% (12%, 67%), and an accuracy of 71%-75% (48%, 91%). Analysis of the MR data showed greater (P = .0038) and faster (P = .0018) enhancement of malignant lesions (n = 12) compared with benign lesions (n = 7). CONCLUSION: Pharmacokinetic mapping of dynamic MR imaging data allows in vivo insight into tissue physiopathology, helping differentiate benign from malignant pelvic lesions in rectal cancer.
Keywords:	Contrast Media, Differential Diagnosis, Drug Combinations, Gadolinium, Gadolinium DTPA, Computer-Assisted Image Processing, Magnetic Resonance Imaging, Meglumine, Local Neoplasm Recurrence, Organometallic Compounds, Pentetic Acid, Predictive Value of Tests, Rectal Neoplasms, Sensitivity and Specificity
Source:	Radiology
ISSN:	0033-8419
Volume:	189
Number:	3
Page Range:	881-889
Date:	1 December 1993
Official Publication:	http://radiology.rsna.org/content/189/3/881.abstract
PubMed:	View item in PubMed

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