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| Item Type: | Article |
|---|---|
| Title: | Retinal damage in multiple sclerosis disease subtypes measured by high-resolution optical coherence tomography |
| Creators Name: | Oberwahrenbrock, T., Schippling, S., Ringelstein, M., Kaufhold, F., Zimmermann, H., Keser, N., Young, K.L., Harmel, J., Hartung, H.P., Martin, R., Paul, F., Aktas, O. and Brandt, A.U. |
| Abstract: | Background: Optical coherence tomography (OCT) has facilitated characterisation of retinal alterations in MS patients. Only scarce and in part conflicting data exists on different MS subtypes. Objective: To analyse patterns of retinal changes in different subtypes of MS with latest spectral-domain technology. Methods: In a three-centre cross-sectional study 414 MS patients and 94 healthy controls underwent spectral-domain OCT examination. Results: Eyes of MS patients without a previous optic neuritis showed a significant reduction of both retinal nerve fibre layer (RNFL) thickness and total macular volume (TMV) compared to healthy controls independent of the MS subtype (P < 0.001 for all subtypes). RNFL thickness was lower in secondary progressive MS (SPMS) eyes compared to relapsing-remitting MS (RRMS) eyes (P = 0.007), and TMV was reduced in SPMS and primary progressive MS (PPMS) eyes compared to RRMS eyes (SPMS: P = 0.039, PPMS: P = 0.005). Independent of the subtype a more pronounced RNFL thinning and TMV reduction were found in eyes with a previous optic neuritis compared to unaffected eyes. Conclusion: Analysis of this large-scale cross-sectional dataset of MS patients studied with spectral-domain OCT confirmed and allows to generalize previous findings. Furthermore it carves out distinct patterns in different MS subtypes. |
| Source: | Multiple Sclerosis International |
| ISSN: | 2090-2654 |
| Publisher: | Hindawi |
| Volume: | 2012 |
| Page Range: | 530305 |
| Date: | 25 July 2012 |
| Official Publication: | https://doi.org/10.1155/2012/530305 |
| PubMed: | View item in PubMed |
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