Aptamer binding and neutralization of beta(1)-adrenoceptor autoantibodies: basics and a vision of its future in cardiomyopathy treatment

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Item Type:	Review
Title:	Aptamer binding and neutralization of beta(1)-adrenoceptor autoantibodies: basics and a vision of its future in cardiomyopathy treatment
Creators Name:	Haberland, A., Wallukat, G. and Schimke, I.
Abstract:	Autoantibodies directed against the second extracellular receptor loop of the beta(1) receptor (beta(1)-ECII-AABs) that belong to the superfamily of G protein-coupled receptors have been frequently found in patients with idiopathic dilated cardiomyopathy, Chagas' cardiomyopathy, and peripartum cardiomyopathy and have been clearly evidenced to be related to disease pathogenesis. Consequently, specific proteins or peptides used as binders in immunoapheresis or as in vivo neutralizers of beta(1)-ECII-AABs have been suggested for patient treatment. Aptamers, which are target specifically selected short single- or double-stranded RNA or DNA sequences, are a recently introduced new molecule class applicable to bind and neutralize diverse molecule species, including antibodies. This article reviews selection technologies and characteristics of aptamers with respect to a single-stranded DNA aptamer recently identified as having a very high affinity against beta(1)-ECII-AABs. The potential of this aptamer for the elimination of beta(1)-ECII-AABs and in vivo neutralization is critically analyzed in view of its potential for future use in cardiomyopathy treatment.
Keywords:	Adrenergic beta-1 Receptor Antagonists, Autoantibodies, beta-1 Receptors, Adrenergic, Blood Component Removal, Cardiomyopathies, Nucleotide Aptamers, Protein Binding, Animals, Mice, Rats
Source:	Trends in Cardiovascular Medicine
ISSN:	1050-1738
Publisher:	Elsevier
Volume:	21
Number:	6
Page Range:	177-182
Date:	August 2011
Official Publication:	https://doi.org/10.1016/j.tcm.2012.05.006
PubMed:	View item in PubMed

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