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| Item Type: | Article |
|---|---|
| Title: | Kainate activates Ca2+-permeable glutamate receptors and blocks voltage-gated K+ currents in glial cells of mouse hippocampal slices |
| Creators Name: | Jabs, R., Kirchhoff, F., Kettenmann, H. and Steinhaeuser, C. |
| Abstract: | Glial cells in the CA1 stratum radiatum of the hippocampus of 9- to 12-day-old mice show intrinsic responses to glutamate due to the activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate receptors. In the present study we have focused on a subpopulation of the hippocampal glial cells, the "complex" cells, characterized by voltage-gated Na+ and K+ channels. Activation of glutamate receptors in these cells led to two types of responses, the activation of a cationic conductance, and a longer-lasting blockade of voltage-gated K+ channels. In particular, the transient (inactivating) component of the outwardly rectifying K+ current was diminished by kainate. Concomitantly, as described in Bergmann glial cells, kainate also elevated cytosolic Ca2+. This increase was due to an influx via the glutamate receptor itself. In contrast to Bergmann glial cells, the cytosolic Ca2+ increase was not a link to the K+ channel blockade, since the blockade occurred in the absence of the Ca2+ signal and, vice versa, an increase in cytosolic Ca2+ induced by ionomycin did not block the transient K+ current. We conclude that glutamate receptor activation leads to complex and variable changes in different types of glial cells; the functional importance of these changes is as yet unresolved. |
| Keywords: | Glial Cell, Hippocampus, Glutamate Receptors, Kainate, Patch Clamp, Potassium Channels, Transmitter Modulation, Animals, Mice |
| Source: | Pfluegers Archiv European Journal of Physiology |
| ISSN: | 0031-6768 |
| Publisher: | Springer |
| Volume: | 426 |
| Number: | 3-4 |
| Page Range: | 310-319 |
| Date: | 1 February 1994 |
| Official Publication: | https://doi.org/10.1007/BF00374787 |
| PubMed: | View item in PubMed |
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