Involvement of claudins in zebrafish brain ventricle morphogenesis

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Item Type:	Article
Title:	Involvement of claudins in zebrafish brain ventricle morphogenesis
Creators Name:	Zhang, J., Liss, M., Wolburg, H., Blasig, I.E. and Abdelilah-Seyfried, S.
Abstract:	Zebrafish brain ventricle morphogenesis involves an initial circulation-independent opening followed by a blood flow- and circulation-dependent expansion process. Zebrafish claudin-5a is required for the establishment of a neuroepithelial-ventricular barrier, which maintains the hydrostatic pressure within the ventricular cavity, thereby contributing to brain ventricle opening and expansion. In mammalia, several claudin family members, including claudin-3 and claudin-5, are expressed within microvessel endothelial cells of the blood-brain barrier. Whether zebrafish brain ventricle morphogenesis provides a model for studying these claudins during early embryonic development was unknown. This review focuses on the expression and function of these zebrafish claudins during brain ventricle morphogenesis.
Keywords:	Brain Ventricle Morphogenesis, Tight Junction, Claudin-5a, Claudin-3, Animals, Zebrafish
Source:	Annals of the New York Academy of Sciences
ISSN:	0077-8923
Publisher:	New York Academy of Sciences
Volume:	1257
Number:	1
Page Range:	193-198
Date:	June 2012
Official Publication:	https://doi.org/10.1111/j.1749-6632.2012.06507.x
PubMed:	View item in PubMed

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