Meat and fish consumption and risk of pancreatic cancer - results from the european prospective investigation into cancer and nutrition

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Item Type:	Article
Title:	Meat and fish consumption and risk of pancreatic cancer - results from the european prospective investigation into cancer and nutrition
Creators Name:	Rohrmann, S., Linseisen, J., Nöthlings, U., Overvad, K., Egeberg, R., Tjønneland, A., Boutron-Ruault, M.C., Clavel-Chapelon, F., Cottet, V., Pala, V., Tumino, R., Palli, D., Panico, S., Vineis, P., Boeing, H., Pischon, T., Grote, V., Teucher, B., Khaw, K.T., Wareham, N.J., Crowe, F.L., Goufa, I., Orfanos, P., Trichopoulou, A., Jeurnink, S.M., Siersema, P.D., Peeters, P.H., Brustad, M., Engeset, D., Skeie, G., Duell, E.J., Amiano, P., Barricarte, A., Molina-Montes, E., Rodríguez, L., Tormo, M.J., Sund, M., Ye, W., Lindkvist, B., Johansen, D., Ferrari, P., Jenab, M., Slimani, N., Ward, H., Riboli, E., Norat, T. and Bas Bueno-de-Mesquita, H.
Abstract:	BACKGROUND: Pancreatic cancer is the fourth most common cause of cancer death worldwide with large geographical variation, which implies the contribution of diet and lifestyle in its etiology. We examined the association of meat and fish consumption with risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). METHODS: Included in our analysis were 477,202 EPIC participants from 10 European countries recruited between 1992 and 2000. Until 2008, 865 non-endocrine pancreatic cancer cases have been observed. Calibrated relative risks (RR) and 95% confidence intervals (CI) were computed using multivariable-adjusted Cox Hazard Regression models. RESULTS: The consumption of red meat (RR per 50 g increase per day 1.03, 95% CI 0.93-1.14) and processed meat (RR per 50 g increase per day 0.93, 95% CI 0.71-1.23) were not associated with an increased pancreatic cancer risk. Poultry consumption tended to be associated with an increased pancreatic cancer risk (RR per 50 g increase per day 1.72, 95% CI 1.04-2.84), but there was not association with fish consumption (RR per 50 g increase per day 1.22, 95% CI 0.92-1.62). CONCLUSION: Our results do not support the conclusion of the World Cancer Research Fund that red or processed meat consumption may possibly increase the risk of pancreatic cancer. The positive association of poultry consumption with pancreatic cancer might be a chance finding as it contradicts most previous findings.
Keywords:	Meat, Fish, Pancreatic Cancer, Cohort, EPIC, Animals, Fishs, Poultry
Source:	International Journal of Cancer
ISSN:	0020-7136
Publisher:	Wiley-Blackwell
Volume:	132
Number:	3
Page Range:	617-624
Date:	1 February 2013
Official Publication:	https://doi.org/10.1002/ijc.27637
PubMed:	View item in PubMed

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