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| Item Type: | Article |
|---|---|
| Title: | Green tea halts progression of cardiac transthyretin amyloidosis: an observational report |
| Creators Name: | Kristen, A.V., Lehrke, S., Buss, S., Mereles, D., Steen, H., Ehlermann, P., Hardt, S., Giannitsis, E., Schreiner, R., Haberkorn, U., Schnabel, P.A., Linke, R.P., Roecken, C., Wanker, E.E., Dengler, T.J., Altland, K. and Katus, H.A. |
| Abstract: | BACKGROUND: Treatment options in patients with amyloidotic transthyretin (ATTR) cardiomyopathy are limited. Epigallocatechin-3-gallate (EGCG), the most abundant catechin in green tea (GT), inhibits fibril formation from several amyloidogenic proteins in vitro. Thus, it might also halt progression of TTR amyloidosis. This is a single-center observational report on the effects of GT consumption in patients with ATTR cardiomopathy. METHODS: 19 patients with ATTR cardiomyopathy were evaluated by standard blood tests, echocardiography, and cardiac MRI (n = 9) before and after consumption of GT and/or green tea extracts (GTE) for 12 months. RESULTS: Five patients were not followed up for reasons of death (n = 2), discontinuation of GT/GTE consumption (n = 2), and heart transplantation (n = 1). After 12 months no increase of left ventricular (LV) wall thickness and LV myocardial mass was observed by echocardiography. In the subgroup of patients evaluated by cardiac MRI a mean decrease of LV myocardial mass (-12.5 %) was detected in all patients. This was accompanied by an increase of mean mitral annular systolic velocity of 9 % in all 14 patients. Total cholesterol (191.9 ± 8.9 vs. 172.7 ± 9.4 mg/dL; p < 0.01) and LDL cholesterol (105.8 ± 7.6 vs. 89.5 ± 8.0 mg/dL; p < 0.01) decreased significantly during the observational period. No serious adverse effects were reported by any of the participants. CONCLUSIONS: Our observation suggests an inhibitory effect of GT and/or GTE on the progression of cardiac amyloidosis. We propose a randomized placebo-controlled investigation to confirm our observation. |
| Keywords: | Cardiomyopathy, Green Tea, Transthyretin-Derived Amyloidosis, Epigallocatechin-3-Gallate |
| Source: | Clinical Research in Cardiology |
| ISSN: | 1861-0684 |
| Publisher: | Springer |
| Volume: | 101 |
| Number: | 10 |
| Page Range: | 805-813 |
| Date: | October 2012 |
| Official Publication: | https://doi.org/10.1007/s00392-012-0463-z |
| PubMed: | View item in PubMed |
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