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| Item Type: | Article |
|---|---|
| Title: | Chromosomal clustering of a human transcriptome reveals regulatory background |
| Creators Name: | Vogel, J.H., von Heydebreck, A., Purmann, A. and Sperling, S. |
| Abstract: | Background. There has been much evidence recently for a link between transcriptional regulation and chromosomal gene order, but the relationship between genomic organization, regulation and gene function in higher eukaryotes remains to be precisely defined. Results: Here, we present evidence for organization of a large proportion of a human transcriptome into gene clusters throughout the genome, which are partly regulated by the same transcription factors, share biological functions and are characterized by non-housekeeping genes. This analysis was based on the cardiac transcriptome identified by our genome-wide array analysis of 55 human heart samples. We found 37% of these genes to be arranged mainly in adjacent pairs or triplets. A significant number of pairs of adjacent genes are putatively regulated by common transcription factors (p = 0.02). Furthermore, these gene pairs share a significant number of GO functional classification terms. We show that the human cardiac transcriptome is organized into many small clusters across the whole genome, rather than being concentrated in a few larger clusters. Conclusion: Our findings suggest that genes expressed in concert are organized in a linear arrangement for coordinated regulation. Determining the relationship between gene arrangement, regulation and nuclear organization as well as gene function will have broad biological implications. |
| Keywords: | Binding Sites, Biological Models, Chromosome Mapping, Gene Expression, Gene Order, Multigene Family, Myocardium, Transcription Factors |
| Source: | BMC Bioinformatics |
| ISSN: | 1471-2105 |
| Publisher: | BioMed Central |
| Volume: | 6 |
| Page Range: | 230 |
| Date: | 19 September 2005 |
| Official Publication: | https://doi.org/10.1186/1471-2105-6-230 |
| PubMed: | View item in PubMed |
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