Coffee consumption and risk of chronic disease in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study

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Item Type:	Article
Title:	Coffee consumption and risk of chronic disease in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study
Creators Name:	Floegel, A., Pischon, T., Bergmann, M.M., Teucher, B., Kaaks, R. and Boeing, H.
Abstract:	BACKGROUND: Early studies suggested that coffee consumption may increase the risk of chronic disease. OBJECTIVE: We investigated prospectively the association between coffee consumption and the risk of chronic diseases, including type 2 diabetes (T2D), myocardial infarction (MI), stroke, and cancer. DESIGN: We used data from 42,659 participants of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study. Coffee consumption was assessed by self-administered food-frequency questionnaire at baseline, and data on medically verified incident chronic diseases were collected by active and passive follow-up procedures. HRs and 95% CIs were calculated with multivariate Cox regression models and compared by competing risk analysis. RESULTS: During 8.9 y of follow-up, we observed 1432 cases of T2D, 394 of MI, 310 of stroke, and 1801 of cancer as first qualifying events. Caffeinated (HR: 0.94; 95% CI: 0.84, 1.05) or decaffeinated (HR: 1.05; 95% CI: 0.84, 1.31) coffee consumption (≥4 cups/d compared with <1 cup/d; 1 cup was defined as 150 mL) was not associated with the overall risk of chronic disease. A lower risk of T2D was associated with caffeinated (HR: 0.77; 95% CI: 0.63, 0.94; P-trend 0.009) and decaffeinated (HR: 0.70; 95% CI: 0.46, 1.06; P-trend: 0.043) coffee consumption (≥4 cups/d compared with <1 cup/d), but cardiovascular disease and cancer risk were not. The competing risk analysis showed no significant differences between the risk associations of individual diseases. CONCLUSION: Our findings suggest that coffee consumption does not increase the risk of chronic disease, but it may be linked to a lower risk of T2D.
Keywords:	Biological Models, Caffein, Cardiovascular Diseases, Coffee, Cohort Studies, Follow-Up Studies, Germany, Incidence, Myocardial Infarction, Neoplasms, Proportional Hazards Models, Prospective Studies, Risk, Risk Assessment, Stroke, Type 2 Diabetes Mellitus
Source:	American Journal of Clinical Nutrition
ISSN:	0002-9165
Publisher:	American Society for Nutrition
Volume:	95
Number:	4
Page Range:	901-908
Date:	April 2012
Official Publication:	https://doi.org/10.3945/ajcn.111.023648
PubMed:	View item in PubMed

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