Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Renoprotective effects of AVE0991, a nonpeptide Mas receptor agonist, in experimental acute renal injury

[thumbnail of 12048oa.pdf] PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
1MB

Item Type:Article
Title:Renoprotective effects of AVE0991, a nonpeptide Mas receptor agonist, in experimental acute renal injury
Creators Name:Barroso, L.C., Silveira, K.D., Lima, C.X., Borges, V., Bader, M., Rachid, M., Souza Santos, R.A., Souza, D.G., Simoes e Silva, A.C. and Teixeira, M.M.
Abstract:Renal ischemia and reperfusion (I/R) is the major cause of acute kidney injury in hospitalized patients. Mechanisms underlying reperfusion-associated injury include recruitment and activation of leukocytes and release of inflammatory mediators. In this study, we investigated the renal effects of acute administration of AVE0991, an agonist of Mas, the angiotensin-(1-7) receptor, the angiotensin-(1-7) receptor, in a murine model of renal I/R. Male C57BL/6 wild-type or Mas(-/-) mice were subjected to 30 min of bilateral ischemia and 24 h of reperfusion. Administration of AVE0991 promoted renoprotective effects, as seen by improvement of function, decreased tissue injury, prevention of local and remote leucocyte infiltration, and release of the chemokine, CXCL1. I/R injury was similar in WT and Mas(-/-) mice, suggesting that endogenous activation of this receptor does not control renal damage under baseline conditions. In conclusion, pharmacological interventions using Mas receptor agonists may represent a therapeutic opportunity for the treatment of renal I/R injury.
Keywords:Animals, Mice
Source:International Journal of Hypertension
ISSN:2090-0392
Publisher:Hindawi
Volume:2012
Page Range:808726
Date:2012
Official Publication:https://doi.org/10.1155/2012/808726
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library