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Increased expression of angiotensin peptides in the brain of transgenic hypertensive rats

Item Type:Article
Title:Increased expression of angiotensin peptides in the brain of transgenic hypertensive rats
Creators Name:Senanayake, P.D., Moriguchi, A., Kumagai, H., Ganten, D., Ferrario, C.M. and Brosnihan, K.B.
Abstract:We determined the levels of angiotensin I (ANG I), angiotensin II (ANG II), and the heptapeptide angiotensin(1-7) [ANG(1-7)] in the blood and brain of female Hannover Sprague-Dawley (SD) and transgenic hypertensive rats [mRen-2]27 by radioimmunoassay and high performance liquid chromatography. Hypertension was accompanied by higher plasma concentrations of ANG II, no statistical changes in ANG(1-7), and no differences in plasma ANG I levels. In the hypothalamus of transgenic rats, concentrations of ANG II and ANG(1-7) averaged 827% and 168% above values in SD rats (p < 0.005) whereas both ANG I and ANG II increased in the medulla oblongata. The data showed that the established phase of hypertension in rats harboring the mouse Ren-2 gene is associated with overexpression of the renin-angiotensin system in brain regions participating in the endocrine regulation of blood pressure.
Keywords:Blood Pressure, Angiotensin I, Angiotensin II, Angiotensin(1–7), Hypertension, Renin Gene, Tissue Renin-Angiotensin System, Animals, Rats
Page Range:919-926
Official Publication:https://doi.org/10.1016/0196-9781(94)90051-5
PubMed:View item in PubMed

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