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| Item Type: | Article |
|---|---|
| Title: | Mas receptors in modulating relaxation induced by perivascular adipose tissue |
| Creators Name: | Lee, R.M.K.W., Bader, M., Alenina, N., Santos, R.A.S., Gao, Y.J. and Lu, C. |
| Abstract: | AIMS: Perivascular adipose tissue (PVAT) is known to secrete vascular relaxation factors, and angiotensin 1-7 [Ang-(1-7)] acting on the endothelium is one of the endothelium-dependent relaxation factors. Mas protein is the receptor for Ang-(1-7). Using aorta from Mas-knockout (K/O) and wild type (FVB) mice, we wished to establish the essential role of Mas receptors in mediating the endothelium-dependent relaxation response induced by relaxation factors from PVAT. MAIN METHODS: Thoracic aortic rings from K/O and FVB mice were prepared with or without PVAT (PVAT+ and PVAT-) and/or intact endothelium (E+) or with the endothelium removed (E-) for functional studies. The contraction and relaxation responses of these vessels to agonist in the presence of different receptor antagonists were studied. KEY FINDINGS: PVAT attenuated the contraction induced by phenylephrine (PHE) in the presence of endothelium only in vessels from FVB mice. Mas receptor antagonists D-Ala-Ang-(1-7) (A779) or D-Pro(7)-Ang-(1-7) enhanced the contraction induced by PHE only in vessels from FVB mice. Ang-(1-7) caused a relaxation response only in E+vessels from FVB mice. Transfer of donor solution from PVAT+ vessels to PVAT- recipient vessels caused a relaxation response among FVB vessels and not among vessels from K/O mice. SIGNIFICANCE: Mas receptors are essential in mediating the endothelium-dependent relaxation response induced by PVAT, therefore highlighting the important role of Ang-(1-7) in the control of vascular functions through PVAT. |
| Keywords: | Mas Receptor, Perivascular Adipose Tissue, Relaxation, Endothelium, Animals, Mice |
| Source: | Life Sciences |
| ISSN: | 0024-3205 |
| Publisher: | Pergamon Press |
| Volume: | 89 |
| Number: | 13-14 |
| Page Range: | 467-472 |
| Date: | 26 September 2011 |
| Official Publication: | https://doi.org/10.1016/j.lfs.2011.07.016 |
| PubMed: | View item in PubMed |
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