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| Item Type: | Article |
|---|---|
| Title: | Antisense oligonucleotide to c-fos induces ipsilateral rotational behaviour to d-amphetamine |
| Creators Name: | Sommer, W., Bjelke, B., Ganten, D. and Fuxe, K. |
| Abstract: | The immediate-early genes, especially c-fos, have been suggested to have an important role in neuronal plasticity and memory. However, it has been difficult to determine if in fact c-fos can participate in control of behaviour. Here we can report that direct unilateral infusion into the rat neostriatum of an antisense phosphothioate oligodeoxynucleotide to c-fos mRNA leads to the rapid induction of ipsilateral rotational behaviour after d-amphetamine administration. This is associated with an elimination of the in vivo expression of Fos-like immunoreactivity within the infused region of neostriatum. Following infusion of these oligodeoxynucleotides labelled with fluorescein isothiocyanate they appear with a nuclear and cytoplasmic location in a large number of nerve cells, many of which are immunoreactive for dopamine and cyclic AMP regulated phosphoprotein. The present findings suggest that the immediate-early gene c-fos has a role also in control of behavioural activity, as illustrated in D1 receptor containing striatal neurones. |
| Keywords: | Base Sequence, Dextroamphetamine, Fluorescein-5-Isothiocyanate, Fos Genes, Immunohistochemistry, Injections, Kinetics, Molecular Sequence Data, Neostriatum, Antisense Oligonucleotides, Stereotyped Behavior, Animals, Rats |
| Source: | NeuroReport |
| ISSN: | 0959-4965 |
| Publisher: | Lippincott Williams & Wilkins |
| Volume: | 5 |
| Number: | 3 |
| Page Range: | 277-280 |
| Date: | 13 December 1993 |
| PubMed: | View item in PubMed |
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