microRNAs and the Operon paper

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Item Type:	Review
Title:	microRNAs and the Operon paper
Creators Name:	Rajewsky, N.
Abstract:	The "Operon paper" by F. Jacob and J. Monod started 50 years of research into understanding how the expression of genes is regulated on a molecular level. Ten years ago, microRNAs emerged as major regulators of eukaryotic gene expression. Here, I will review basic principles of gene regulation by microRNAs and how these principles can be linked to insights from the Operon paper. A lot of what is understood about microRNAs required a combination of computational and experimental methods. I will discuss some examples that illustrate the power of this approach.
Keywords:	miRNAs, Posttranscriptional, Gene Regulation, Operon Model
Source:	Journal of Molecular Biology
ISSN:	0022-2836
Publisher:	Elsevier
Volume:	409
Number:	1
Page Range:	70-75
Date:	27 May 2011
Official Publication:	https://doi.org/10.1016/j.jmb.2011.03.021
PubMed:	View item in PubMed

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