Prediagnostic circulating parathyroid hormone concentration and colorectal cancer in the European prospective investigation into cancer and nutrition cohort

Tools

Item Type:	Article
Title:	Prediagnostic circulating parathyroid hormone concentration and colorectal cancer in the European prospective investigation into cancer and nutrition cohort
Creators Name:	Fedirko, V., Riboli, E., Bueno-de-Mesquita, H.B., Rinaldi, S., Pischon, T., Norat, T., Jansen, E., van Duijnhoven, F., Tjonneland, A.M., Olsen, A., Overvad, K., Boutron-Ruault, M.C., Clavel-Chapelon, F., Engel, P., Kaaks, R., Teucher, B., Boeing, H., Buijsse, B., Trichopoulou, A., Trichopoulos, D., Lagiou, P., Sieri, S.A., Vineis, P., Panico, S., Palli, D., Tumino, R., van Gils, C.H., Peeters, P.H., Chirlaque, M.D., Barricarte Gurrea, A., Rodriguez, L., Molina-Montes, E., Dorronsoro, M., Bonet, C., Palmqvist, R., Hallmans, G., Key, T.J., Tsilidis, K.K., Khaw, K.T., Romieu, I., Straif, K., Wark, P.A., Romaguera, D. and Jenab, M.
Abstract:	Background: Parathyroid hormone (PTH) has been proposed to play a promoting role in carcinogenesis. However, no epidemiologic studies have yet directly investigated its role in colorectal cancer (CRC). Methods: A case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort was conducted with 1,214 incident, sporadic CRC cases matched to 1,214 controls. Circulating pre-diagnostic PTH and 25-hydroxy vitamin D [25(OH)D] concentrations were measured by enzyme-linked immunosorbent assays. Detailed dietary and lifestyle questionnaire data were collected at baseline. Multivariable conditional logistic regression was used to estimate the incidence rate ratio (RR) with 95% confidence intervals (95%CI) for the association between circulating PTH and CRC risk. RESULTS: In multivariate analyses (including adjustment for 25(OH)D concentration) with a priori defined cut-points, high levels of serum PTH (>=65ng/L) compared to medium PTH levels of 30-65 ng/L were associated with increased CRC risk (RR=1.41, 95%CI: 1.03-1.93). In analyses by sex, the CRC risk was 1.77 (95%CI: 1.14-2.75) and 1.15 (95%CI: 0.73-1.84) in men and women, respectively (Pheterogeneity=0.01). In sub-group analyses by anatomical sub-site, the risk for colon cancer was RR=1.56, 95%CI:1.03-2.34, and for rectal cancer RR=1.20, 95%CI:0.72-2.01 (Pheterogeneity=0.21). Effect modification by various risk factors was examined. Conclusions: The results of this study suggest that high serum PTH levels may be associated with incident, sporadic CRC in Western European populations, and in particular among men. Impact: To our knowledge, this is the first study on PTH and CRC. The role of PTH in carcinogenesis needs to be further investigated.
Keywords:	Parathyroid Hormone, Colorectal Neoplasms, Nested Case-Control Studies, Observational Studies, Colorectal Cancer
Source:	Cancer Epidemiology Biomarkers & Prevention
ISSN:	1055-9965
Publisher:	American Association for Cancer Research
Volume:	20
Number:	5
Page Range:	767-778
Date:	May 2011
Official Publication:	https://doi.org/10.1158/1055-9965.EPI-10-1212
PubMed:	View item in PubMed

Repository Staff Only: item control page