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| Item Type: | Article |
|---|---|
| Title: | Fatigue in multiple sclerosis is closely related to sleep disorders: a polysomnographic cross-sectional study |
| Creators Name: | Veauthier, C., Radbruch, H., Gaede, G., Pfueller, C., Doerr, J., Bellmann-Strobl, J., Wernecke, K.D., Zipp, F., Paul, F. and Sieb, J. |
| Abstract: | Background: Sleep disorders can cause tiredness. The relationship between sleep disorders and fatigue in patients with multiple sclerosis (MS) has not yet been investigated systematically. Objective: To investigate the relationship between fatigue and sleep disorders in patients with MS. Methods: Some 66 MS patients 20 to 66 years old were studied by overnight polysomnography. Using a cut-off point of 45 in the Modified Fatigue Impact Scale (MFIS), the entire cohort was stratified into a fatigued MS subgroup (n = 26) and a non-fatigued MS subgroup (n = 40). Results: Of the fatigued MS patients, 96% (n = 25) were suffering from a relevant sleep disorder, along with 60% of the non-fatigued MS patients (n = 24) (p = 0.001). Sleep-related breathing disorders were more frequent in the fatigued MS patients (27%) than in the non-fatigued MS patients (2.5%). Significantly higher MFIS values were detected in all (fatigued and non-fatigued) patients with relevant sleep disorders (mean MFIS 42.8; SD 18.3) than in patients without relevant sleep disorders (mean MFIS 20.5; SD 17.0) (p < 0.001). Suffering from a sleep disorder was associated with an increased risk of fatigue in MS (odds ratio: 18.5; 95% CI 1.6-208; p = 0.018). Conclusion: Our results demonstrate a clear and significant relationship between fatigue and sleep disorders. |
| Keywords: | Fatigue, Insomnia, Periodic Limb Movement Disorder, Polysomnography, Restless Legs Syndrome, Sleep Apnoea Syndromes, Tiredness |
| Source: | Multiple Sclerosis Journal |
| ISSN: | 1352-4585 |
| Publisher: | Sage Publications |
| Volume: | 17 |
| Number: | 5 |
| Page Range: | 613-622 |
| Date: | May 2011 |
| Official Publication: | https://doi.org/10.1177/1352458510393772 |
| PubMed: | View item in PubMed |
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