Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition

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Item Type:	Article
Title:	Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition
Creators Name:	Friedenreich, C., Cust, A., Lahmann, P.H., Steindorf, K., Boutron-Ruault, M.C., Clavel-Chapelon, F., Mesrine, S., Linseisen, J., Rohrmann, S., Boeing, H., Pischon, T., Tjonneland, A., Halkjaer, J., Overvad, K., Mendez, M., Redondo, M.L., Garcia, C.M., Larranaga, N., Tormo, M.J., Gurrea, A.B., Bingham, S., Khaw, K.T., Allen, N., Key, T., Trichopoulou, A., Vasilopoulou, E., Trichopoulos, D., Pala, V., Palli, D., Tumino, R., Mattiello, A., Vineis, P., Bueno-de-Mesquita, H.B., Peeters, P.H., Berglund, G., Manjer, J., Lundin, E., Lukanova, A., Slimani, N., Jenab, M., Kaaks, R. and Riboli, E.
Abstract:	Objective: To examine the association between anthropometry and endometrial cancer, particularly by menopausal status and exogenous hormone use subgroups.Methods: Among 223,008 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, there were 567 incident endometrial cancer cases during 6.4 years of follow-up. The analysis was performed with Cox proportional hazards modeling.Results: Weight, body mass index (BMI), waist and hip circumferences and waist-hip ratio (WHR) were strongly associated with increased risk of endometrial cancer. The relative risk (RR) for obese (BMI 30- < 40 kg/m(2)) compared to normal weight (BMI < 25) women was 1.78, 95% CI = 1.41-2.26, and for morbidly obese women (BMI > or = 40) was 3.02, 95% CI = 1.66-5.52. The RR for women with a waist circumference of > or =88 cm vs. <80 cm was 1.76, 95% CI = 1.42-2.19. Adult weight gain of > or =20 kg compared with stable weight (+/-3 kg) increased risk independent of body weight at age 20 (RR = 1.75, 95% CI = 1.11-2.77). These associations were generally stronger for postmenopausal than premenopausal women, and oral contraceptives never-users than ever-users, and much stronger among never-users of hormone replacement therapy compared to ever-users.Conclusion: Obesity, abdominal adiposity, and adult weight gain were strongly associated with endometrial cancer risk. These associations were particularly evident among never-users of hormone replacement therapy.
Keywords:	Anthropometry, Endometrial Cancer, Etiology, Risk Factors, Obesity, Adiposity, Mechanisms, Hormone Replacement Therapy
Source:	Cancer Causes & Control
ISSN:	0957-5243
Publisher:	Springer
Volume:	18
Number:	4
Page Range:	399-413
Date:	May 2007
Official Publication:	https://doi.org/10.1007/s10552-006-0113-8
PubMed:	View item in PubMed

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