![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
| Item Type: | Article |
|---|---|
| Title: | Single nucleotide polymorphisms at the adiponectin locus and risk of coronary heart disease in men and women |
| Creators Name: | Pischon, T., Pai, J.K., Manson, J.E., Hu, F.B., Rexrode, K.M., Hunter, D. and Rimm, E.B. |
| Abstract: | OBJECTIVE: The objective was to examine the association of 5 common single nucleotide polymorphisms (SNPs) at the adiponectin locus with risk of coronary heart disease (CHD) in men and women. METHODS AND PROCEDURES: We genotyped five common SNPs in the adiponectin gene (rs266729, -11365C>G; rs822395, -4034A>C; rs822396, -3964A>G; rs2241766, +45T>G; and rs1501299, +276G>T) in men (Health Professionals Follow-up Study) and women (Nurses' Health Study) in a nested case control setting. Among participants free of cardiovascular disease at baseline, 266 men and 249 women developed non-fatal myocardial infarction or fatal CHD during 6 and 8 years of follow-up, respectively. In addition, 564 men had coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty. Using risk set sampling, controls were selected 2:1 matched on age, smoking, and date of blood draw. RESULTS: The -4034CC genotype was related to an increased risk of non-fatal myocardial infarction or fatal CHD compared with the AA genotype [relative risk (RR), men, 1.69; 95% confidence interval (CI), 0.99 to 2.89; women, 2.04; 95% CI, 1.20 to 3.49); however, this genotype was not related to risk of coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty or to plasma adiponectin levels. Other SNPs or haplotypes defined by the 5 SNPs were not consistently related to risk of CHD in men and women or to plasma adiponectin levels. DISCUSSION: Our study does not support the hypothesis that these 5 common SNPs in the adiponectin gene play an important role in the development of CHD among men and women, although we cannot exclude an association between the -4034CC genotype and risk of CHD. |
| Keywords: | Genetics, Epidemiology, Coronary Heart Disease, Polymorphism |
| Source: | Obesity |
| ISSN: | 1930-7381 |
| Publisher: | NAASO The Obesity Society |
| Volume: | 15 |
| Number: | 8 |
| Page Range: | 2051-2060 |
| Date: | August 2007 |
| Official Publication: | https://doi.org/10.1038/oby.2007.244 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
