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Cardiac arrhythmia and thyroid dysfunction: a novel genetic link

Item Type:Article
Title:Cardiac arrhythmia and thyroid dysfunction: a novel genetic link
Creators Name:Purtell, K., Roepke, T.K. and Abbott, G.W.
Abstract:Inherited Long QT Syndrome (LQTS), a cardiac arrhythmia that predisposes to the often lethal ventricular fibrillation, is commonly linked to mutations in KCNQ1. The KCNQ1 voltage-gated K(+) channel α subunit passes ventricular myocyte K(+) current that helps bring a timely end to each heart-beat. KCNQ1, like many K(+) channel alpha subunits, is regulated by KCNE beta subunits, inherited mutations in which also associate with LQTS. KCNQ1 and KCNE mutations are also associated with atrial fibrillation. It has long been known that thyroid status strongly influences cardiac function, and that thyroid dysfunction causes abnormal cardiac structure and rhythm. We recently discovered that KCNQ1 and KCNE2 form a thyroid-stimulating hormone-stimulated K(+) channel in the thyroid that is required for normal thyroid hormone biosynthesis. Here, we review this novel genetic link between cardiac and thyroid physiology and pathology, and its potential influence upon future therapeutic strategies in cardiac and thyroid disease.
Keywords:Atrial Fibrillation, Hypothyroidism, Hyperthyroidism, KCNE2, KCNQ1, Long QT Syndrome, MiRP1, Animals
Source:International Journal of Biochemistry and Cell Biology
Page Range:1767-1770
Date:November 2010
Official Publication:https://doi.org/10.1016/j.biocel.2010.07.013
PubMed:View item in PubMed

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