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| Item Type: | Article |
|---|---|
| Title: | Cellular senescence predicts treatment outcome in metastasised colorectal cancer |
| Creators Name: | Haugstetter, A.M., Loddenkemper, C., Lenze, D., Groene, J., Standfuss, C., Petersen, I., Doerken, B. and Schmitt, C.A. |
| Abstract: | Background: Cellular senescence is a terminal cell-cycle arrest that occurs in response to activated oncogenes and DNA-damaging chemotherapy. Whether cancer cell senescence at diagnosis might be predictive for treatment outcome is unknown. Methods: A senescence index (SI) was developed and used to retrospectively correlate the treatment outcome of 30 UICC stage IV colorectal cancer (CRC) patients with their SI at diagnosis. Results: 5-Fluorouracil/leucovorin-treated CRC patients achieved a significantly longer progression-free survival when presenting with SI-positive tumours before therapy (median 12.0 vs 6.0 months; P=0.044). Conclusion: Cancer cell senescence predicts treatment outcome in metastasised CRC. Prospective analyses of larger patient cohorts are needed. |
| Keywords: | Cellular Senescence, Colorectal Cancer, Ras Mutations, Treatment Outcome |
| Source: | British Journal of Cancer |
| ISSN: | 0007-0920 |
| Publisher: | Nature Publishing Group |
| Volume: | 103 |
| Number: | 4 |
| Page Range: | 505-509 |
| Date: | 10 August 2010 |
| Official Publication: | https://doi.org/10.1038/sj.bjc.6605784 |
| PubMed: | View item in PubMed |
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