Stochastic spreading of intracellular Ca(2+) release

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Item Type:	Article
Title:	Stochastic spreading of intracellular Ca(2+) release
Creators Name:	Falcke, M., Tsimring, L. and Levine, H.
Abstract:	We study the spreading of calcium-induced calcium release with the stochastic DeYoung-Keizer-model of the inositol 1,4,5-trisphosphate receptor channel. The model shows a transition from isolated release events to steadily propagating waves with increasing IP3 concentration. A state--stochastic backfiring--was found in the regime of steady propagation. The model can be reduced by an adiabatic elimination of the partial differential equation for the Ca(2+) concentration to a lattice of stochastic channel clusters.
Keywords:	Calcium, Calcium Channels, Calcium Signaling, Computer Simulation, Inositol 1,4,5-Trisphosphate, Inositol 1,4,5-Trisphosphate Receptors, Biological Models, Probability, Cytoplasmic and Nuclear Receptors, Stochastic Processes
Source:	Physical Review E
ISSN:	1063-651X
Publisher:	American Physical Society
Volume:	62
Number:	2 Pt B
Page Range:	2636-2643
Date:	August 2000
Official Publication:	https://doi.org/10.1103/PhysRevE.62.2636
PubMed:	View item in PubMed

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