Reactive clusters on a membrane

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Item Type:	Article
Title:	Reactive clusters on a membrane
Creators Name:	Thul, R. and Falcke, M.
Abstract:	We investigate the reaction dynamics of diffusive molecules with immobile binding partners. The fixed reactants build clusters that are comprised of just a few tens of molecules, which leads to small cluster sizes. These molecules participate in the reaction only if they are activated. The dynamics of activation is mapped to a time-dependent size of an active region within the cluster. We focus on the deterministic description of the dynamics of a single cluster. The spatial setup accounts for one of the most important determinants of the dynamics of a cluster, i.e. diffusional transport of reaction partners towards or away from the active region of the cluster. We provide numerical and analytical evidence that diffusion influences decisively the dynamic regimes of the reactions. The application of our methods to intracellular Ca2+ dynamics shows that large local concentrations saturate the Ca2+ feedback to the channel state control. It eliminates oscillations depending on this feedback.
Keywords:	Biophysics, Calcium, Calcium Channels, Calcium Signaling, Cell Membrane, Diffusion, Inositol 1,4,5-Trisphosphate Receptors, Biological Models, Chemical Models, Statistical Models, Theoretical Models, Oscillometry, Stochastic Processes, Animals
Source:	Physical Biology
ISSN:	1478-3967
Publisher:	Institute of Physics
Volume:	2
Number:	1
Page Range:	51-59
Date:	March 2005
Official Publication:	https://doi.org/10.1088/1478-3967/2/1/007
PubMed:	View item in PubMed

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