Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats

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Item Type:	Article
Title:	Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats
Creators Name:	Hilbert, P., Lindpaintner, K., Beckmann, J.S., Serikawa, T., Soubrier, F., Dubay, C.J., Cartwright, P., De Gouyon, B., Julier, C., Takahashi, S., Vincent, M., Ganten, D., Georges, M. and Lathrop, G.M.
Abstract:	The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure. Linkage studies in crosses between the stroke-prone spontaneously hypertensive rat and the normotensive control strain Wistar-Kyoto have led to the localization of two genes, BP/SP-1 and BP/SP-2, that contribute significantly to blood pressure variation in the F2 population. BP/SP-1 and BP/SP-2 were assigned to rat chromosomes 10 and X, respectively. Comparison of the human and rat genetic maps indicates that BP/SP-1 could reside on human chromosome 17q in a region that also contains the angiotensin I-converting enzyme gene (ACE). This encodes a key enzyme of the renin-angiotensin system, and is therefore a candidate gene in primary hypertension. A rat microsatellite marker of ACE was mapped to rat chromosome 10 within the region containing BP/SP-1.
Keywords:	Base Sequence, Cell Surface Receptors, Chromosome Mapping, Genetic Linkage, Hypertension, Molecular Sequence Data, Nerve Growth Factor Receptors, Peptidyl-Dipeptidase A, Polymerase Chain Reaction, Somatotropin Receptors, X Chromosome, Animals, Rats
Source:	Nature
ISSN:	0028-0836
Publisher:	Nature Publishing Group
Volume:	353
Number:	6344
Page Range:	521-529
Date:	10 October 1991
Official Publication:	https://doi.org/10.1038/353521a0
PubMed:	View item in PubMed

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