Molecular physiology of anion channels

Tools

Item Type:	Article
Title:	Molecular physiology of anion channels
Creators Name:	Jentsch, T.J.
Abstract:	Anion channels have diverse functions, ranging from regulation of cell volume to transepithelial transport and control of excitability. Three well established structural classes of plasma membrane chloride channels now exist: the ligand-gated chloride channels, the cAMP-stimulated cystic fibrosis transmembrane conductance regulator channel, and the voltage-gated (or swelling-activated) members of the CLC chloride channel family. Genetic defects leading to inherited disease are known for each of these classes. A combination of mutagenesis and biophysical analysis has been used to correlate their structure with function. Recently, the role of several molecules has been questioned; rather than being chloride channels themselves, they may be activators of endogenous channels in the cells used for expression.
Keywords:	Chloride Channels, Cystic Fibrosis, Electric Conductivity, Ion Channel Gating, Membrane Proteins
Source:	Current Opinion in Cell Biology
ISSN:	0955-0674
Publisher:	Elsevier / Current Biology
Volume:	6
Number:	4
Page Range:	600-606
Date:	August 1994
Official Publication:	https://doi.org/10.1016/0955-0674(94)90082-5
PubMed:	View item in PubMed

Repository Staff Only: item control page