Chloride channels: a molecular perspective

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Item Type:	Article
Title:	Chloride channels: a molecular perspective
Creators Name:	Jentsch, T.J.
Abstract:	Plasma membrane Cl- channels perform a variety of functions, including control of excitability in neurons and muscle, cell volume regulation and transepithelial transport. Structurally, three classes of Cl- channels have been identified: ligand-gated, postsynaptic Cl- channels (e.g. GABA and glycine receptors); the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels (which belong to the traffic ATPase superfamily); and the CLC family of Cl- channels. Recent developments of note include further characterization of the expanding CLC Cl- channel family, advances in understanding the regulation of the CFTR Cl- channel and its emergent role as a regulator of other channels, clarification of issues related to swelling-activated Cl- channels, and the discovery that several co-transporter molecules are now known to induce Cl- currents in Xenopus oocytes.
Keywords:	Carrier Proteins, Chloride Channels, Cystic Fibrosis Transmembrane Conductance Regulator, Electric Conductivity, Oocytes, Osmosis, Animals
Source:	Current Opinion in Neurobiology
ISSN:	0959-4388
Publisher:	Current Biology
Volume:	6
Number:	3
Page Range:	303-310
Date:	June 1996
Official Publication:	https://doi.org/10.1016/S0959-4388(96)80112-7
PubMed:	View item in PubMed

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