Circulating endocannabinoid concentrations during orthostatic stress

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Item Type:	Article
Title:	Circulating endocannabinoid concentrations during orthostatic stress
Creators Name:	Schroeder, C., Batkai, S., Engeli, S., Tank, J., Diedrich, A., Luft, F.C. and Jordan, J.
Abstract:	BACKGROUND: In animals, the endocannabinoid system is activated during hemodynamic insults and restrains blood pressure in part through sympathetic inhibition. MATERIALS AND METHODS: We tested the hypothesis that hemodynamic stress elicited by head-up tilt testing increases systemic endocannabinoid concentrations in humans and that excessive endocannabinoid availability predisposes to presyncope. RESULTS: With head-up tilt, 2-arachidonoylglycerol increased, whereas anandamide remained unchanged. CONCLUSIONS: In contrast to our expectations, anandamide plasma concentration at rest was directly correlated with orthostatic tolerance, rather than intolerance.
Keywords:	Anandamide, 2-Arachidonoylglycerol, Endocannabinoids, Syncope, Head-Up Tilt
Source:	Clinical Autonomic Research
ISSN:	0959-9851
Publisher:	Springer
Volume:	19
Number:	6
Page Range:	343-346
Date:	December 2009
Official Publication:	https://doi.org/10.1007/s10286-009-0026-1
PubMed:	View item in PubMed

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