Urinary NGAL marks cystic disease in HIV-associated nephropathy

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Item Type:	Article
Title:	Urinary NGAL marks cystic disease in HIV-associated nephropathy
Creators Name:	Paragas, N., Nickolas, T.L., Wyatt, C., Forster, C.S., Sise, M., Morgello, S., Jagla, B., Buchen, C., Stella, P., Sanna-Cherchi, S., Carnevali, M.L., Mattei, S., Bovino, A., Argentiero, L., Magnano, A., Devarajan, P., Schmidt-Ott, K.M., Allegri, L., Klotman, P., D'Agati, V., Gharavi, A.G. and Barasch, J.
Abstract:	Nephrosis and a rapid decline in kidney function characterize HIV-associated nephropathy (HIVAN). Histologically, HIVAN is a collapsing focal segmental glomerulosclerosis with prominent tubular damage. We explored the expression of neutrophil gelatinase-associated lipocalin (NGAL), a marker of tubular injury, to determine whether this protein has the potential to aid in the noninvasive diagnosis of HIVAN. We found that expression of urinary NGAL was much higher in patients with biopsy-proven HIVAN than in HIV-positive and HIV-negative patients with other forms of chronic kidney disease. In the HIV-transgenic mouse model of HIVAN, NGAL mRNA was abundant in dilated, microcystic segments of the nephron. In contrast, urinary NGAL did not correlate with proteinuria in human or in mouse models. These data show that marked upregulation of NGAL accompanies HIVAN and support further study of uNGAL levels in large cohorts to aid in the noninvasive diagnosis of HIVAN and screen for HIVAN-related tubular damage.
Keywords:	AIDS-Associated Nephropathy, Acute-Phase Proteins, Lipocalins, Proto-Oncogene Proteins, Animals, Mice
Source:	Journal of the American Society of Nephrology
ISSN:	1046-6673
Publisher:	American Society of Nephrology
Volume:	20
Number:	8
Page Range:	1687-1692
Date:	1 August 2009
Official Publication:	https://doi.org/10.1681/ASN.2009010065
PubMed:	View item in PubMed

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