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| Item Type: | Review |
|---|---|
| Title: | Shaping the zebrafish heart: from left-right axis specification to epithelial tissue morphogenesis |
| Creators Name: | Bakkers, J., Verhoeven, M.C. and Abdelilah-Seyfried, S. |
| Abstract: | Although vertebrates appear bilaterally symmetric on the outside, various internal organs, including the heart, are asymmetric with respect to their position and/or their orientation based on the left/right (L/R) axis. The L/R axis is determined during embryo development. Determination of the L/R axis is fundamentally different from the determination of the anterior-posterior or the dorsal-ventral axis. In all vertebrates a ciliated organ has been described that induces a left-sided gene expression program, which includes Nodal expression in the left lateral plate mesoderm. To have a better understanding of organ laterality it is important to understand how L/R patterning induces cellular responses during organogenesis. In this review, we discuss the current understanding of the mechanisms of L/R patterning during zebrafish development and focus on how this affects cardiac morphogenesis. Several recent studies have provided unprecedented insights into the intimate link between L/R signaling and the cellular responses that drive morphogenesis of this organ. |
| Keywords: | Left-Right Patterning, Laterality, Heart, Animals, Zebrafish |
| Source: | Developmental Biology |
| ISSN: | 0012-1606 |
| Publisher: | Academic Press |
| Volume: | 330 |
| Number: | 2 |
| Page Range: | 213-220 |
| Date: | 15 June 2009 |
| Official Publication: | https://doi.org/10.1016/j.ydbio.2009.04.011 |
| PubMed: | View item in PubMed |
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