Shaping the zebrafish heart: from left-right axis specification to epithelial tissue morphogenesis

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Item Type:	Review
Title:	Shaping the zebrafish heart: from left-right axis specification to epithelial tissue morphogenesis
Creators Name:	Bakkers, J., Verhoeven, M.C. and Abdelilah-Seyfried, S.
Abstract:	Although vertebrates appear bilaterally symmetric on the outside, various internal organs, including the heart, are asymmetric with respect to their position and/or their orientation based on the left/right (L/R) axis. The L/R axis is determined during embryo development. Determination of the L/R axis is fundamentally different from the determination of the anterior-posterior or the dorsal-ventral axis. In all vertebrates a ciliated organ has been described that induces a left-sided gene expression program, which includes Nodal expression in the left lateral plate mesoderm. To have a better understanding of organ laterality it is important to understand how L/R patterning induces cellular responses during organogenesis. In this review, we discuss the current understanding of the mechanisms of L/R patterning during zebrafish development and focus on how this affects cardiac morphogenesis. Several recent studies have provided unprecedented insights into the intimate link between L/R signaling and the cellular responses that drive morphogenesis of this organ.
Keywords:	Left-Right Patterning, Laterality, Heart, Animals, Zebrafish
Source:	Developmental Biology
ISSN:	0012-1606
Publisher:	Academic Press
Volume:	330
Number:	2
Page Range:	213-220
Date:	15 June 2009
Official Publication:	https://doi.org/10.1016/j.ydbio.2009.04.011
PubMed:	View item in PubMed

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