Single- or dual-bolus approach for the assessment of myocardial perfusion reserve in quantitative MR perfusion imaging

Item Type:	Article
Title:	Single- or dual-bolus approach for the assessment of myocardial perfusion reserve in quantitative MR perfusion imaging
Creators Name:	Utz, W. and Greiser, A. and Niendorf, T. and Dietz, R. and Schulz-Menger, J.
Abstract:	A dual-bolus protocol can overcome limitations due to T1-induced MR signal attenuation and hence enables more accurate quantification of myocardial blood flow (MBF) by contrast enhanced MR perfusion imaging. The study explores potential benefits of the dual-bolus technique for the assessment of myocardial perfusion reserve (MPR) over a standard single-bolus protocol. Nineteen patients without obstructive coronary artery disease as assessed by cardiac catheterization underwent a stress-rest MR perfusion study using a dual-bolus protocol. Gd-DTPA dosages of 0.005 and 0.05 mmol/kg of bodyweight were delivered as pre- and main-bolus. For comparison arterial input curves where extracted from left ventricular cavity passage including both, pre-bolus and main-bolus data. Global and segmental MPR were determined from semiquantitative and from full quantitative measures of MBF. As a result good agreement between dual- and single-bolus technique was found with relative differences of maximally 10% in global MPR estimates. For the dual bolus approach a significant relative decrease of 30% (P < 0.001) was found for the coefficient of segmental MPR variation, which may allow a more reliable detection of hypoperfused segments in clinical studies.
Keywords:	Magnetic Resonance Imaging, First-Pass Perfusion, Contrast Agent, Perfusion Reserve
Source:	Magnetic Resonance in Medicine
ISSN:	0740-3194
Publisher:	Wiley
Volume:	59
Number:	6
Page Range:	1373-1377
Date:	June 2008
Official Publication:	https://doi.org/10.1002/mrm.21611
PubMed:	View item in PubMed

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