Contrast-dose relation in first-pass myocardial MR perfusion imaging

Item Type:	Article
Title:	Contrast-dose relation in first-pass myocardial MR perfusion imaging
Creators Name:	Utz, W. and Niendorf, T. and Wassmuth, R. and Messroghli, D. and Dietz, R. and Schulz-Menger, J.
Abstract:	Purpose: To determine the regime of linear contrast enhancement in human first-pass perfusion cardiovascular magnetic resonance (CMR) imaging to improve accuracy in myocardial perfusion quantification. Materials and Methods: A total of 10 healthy subjects were studied on a clinical 1.5T MR scanner. Seven doses of Gd-DTPA ranging from 0.00125 to 0.1 mmol/kg of body weight (b.w.) were administered as equal volumes by rapid bolus injection (6 mL/second). Resting periods of 15 minutes were introduced after delivery of Gd doses >gt;0.01 mmol/kg b.w. For each subject, two series of rest perfusion scans were performed using two different multislice saturation-recovery perfusion sequences. Maximum contrast enhancement and maximum upslope were obtained in the blood pool of the left ventricular (LV) cavity and in the myocardium. The range of linear contrast-dose relation was determined by linear regression analysis. Results: MR signal intensity increased linearly for contrast agent concentrations up to 0.01 mmol/kg b.w. in the LV blood pool and up to 0.05 mmol/kg b.w. in the myocardium. For Gd concentrations exceeding these thresholds the signal intensity response was not linear with respect to the contrast agent dose. Conclusion: Quantitative evaluation of cardiac MR perfusion data needs to account for signal saturation in both the LV blood pool and the myocardium.
Keywords:	Heart, Magnetic Resonance, Myocardial Perfusion, Gadolinium, Contrast Agent, Arterial Input Function
Source:	Journal of Magnetic Resonance Imaging
ISSN:	1053-1807
Publisher:	Wiley
Volume:	25
Number:	6
Page Range:	1131-1135
Date:	June 2007
Official Publication:	https://doi.org/10.1002/jmri.20910
PubMed:	View item in PubMed

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