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| Item Type: | Article |
|---|---|
| Title: | Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions |
| Creators Name: | Brembeck, F.H. and Schwarz-Romond, T. and Bakkers, J. and Wilhelm, S. and Hammerschmidt, M. and Birchmeier, W. |
| Abstract: | {Beta}-Catenin controls both cadherin-mediated cell adhesion and activation of Wnt target genes. We demonstrate here that the {beta}-catenin-binding protein BCL9-2, a homolog of the human proto-oncogene product BCL9, induces epithelial-mesenchymal transitions of nontransformed cells and increases {beta}-catenin-dependent transcription. RNA interference of BCL9-2 in carcinoma cells induces an epithelial phenotype and translocates {beta}-catenin from the nucleus to the cell membrane. The switch between {beta}-catenin's adhesive and transcriptional functions is modulated by phosphorylation of Tyr 142 of {beta}-catenin, which favors BCL9-2 binding and precludes interaction with {alpha}-catenin. During zebrafish embryogenesis, BCL9-2 acts in the Wnt8-signaling pathway and regulates mesoderm patterning. |
| Keywords: | {Alpha}-Catenin, BCL9, Epithelial-Mesenchymal Transition, Mesoderm Patterning, Tyrosine Phosphorylationp, Wnt8, Animals, Mice, Zebrafish |
| Source: | Genes & Development |
| ISSN: | 0890-9369 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Volume: | 18 |
| Number: | 18 |
| Page Range: | 2225-2230 |
| Date: | 15 September 2004 |
| Official Publication: | https://doi.org/10.1101/gad.317604 |
| PubMed: | View item in PubMed |
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