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A dual role for lkkalpha in tooth development

Item Type:Article
Title:A dual role for lkkalpha in tooth development
Creators Name:Ohazama, A. and Hu, Y.L. and Schmidt-Ullrich, R. and Cao, Y.X. and Scheidereit, C. and Karin, M. and Sharpe, P.T.
Abstract:IKK{alpha} is a component of the I{kappa}B kinase (IKK) complex that plays a key role in the activation of NF-{kappa}B. In Ikk{alpha} mutant mice and mice expressing a transdominant negative mutant of I{kappa}B{alpha} (cI{kappa}B{alpha}ΔN), molars have abnormal cusps, indicating that Ikk{alpha} is involved in cusp formation through the NF-{kappy}B pathway. However, Ikk{alpha} mutant incisors also have an earlier phenotype where epithelium evaginates outward into the developing oral cavity rather than invaginating into the underlying mesenchyme. A similar evagination of epithelium was also observed in whisker development, suggesting that Ikk{alpha} contributes to the direction of epithelial growth during the early stages of development in many ectodermal appendages. Since cI{kappa}B{alpha}ΔN mice have normal incisor epithelial invagination, Ikk{alpha}'s role appears to be NF-{kappa}B independent. Changes in Notch1, Notch2, Wnt7b, and Shh expression found in incisor epithelium of Ikk{alpha} mutants suggest that this NF-{kappa}B-independent function is mediated by Notch/Wnt/Shh signaling pathways.
Keywords:beta-Galactosidase, Body Patterning, Gene Deletion, Gene Expression Regulation, Genetic Models, I-kappa B Kinase, I-kappa B Proteins, In Situ Hybridization, Jaw, Mammalian Embryo, Membrane Proteins, NF-kappa B, Notch Receptors, Protein-Serine-Threonine Kinases, Signal Transduction, Time Factors, Tooth, Transgenic Mice, Animals, Mice
Source:Developmental Cell
Publisher:Cell Press
Page Range:219-227
Date:1 January 2004
Official Publication:https://doi.org/10.1016/S1534-5807(04)00024-3
PubMed:View item in PubMed

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