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Jagged1-induced notch signaling drives proliferation of multiple myeloma cells

Item Type:Article
Title:Jagged1-induced notch signaling drives proliferation of multiple myeloma cells
Creators Name:Jundt, F. and Schulze-Proebsting, K. and Anagnostopoulos, I. and Muehlinghaus, G. and Chatterjee, M. and Mathas, S. and Bargou, R.C. and Manz, R. and Stein, H. and Doerken, B.
Abstract:Notch receptors expressed on hematopoietic stem cells interact with their ligands on bone marrow stromal cells and thereby control cell fate decisions and survival. We recently demonstrated that Notch signaling is involved in proliferation and survival of B cell-derived tumor cells of classic Hodgkin disease and described a novel mechanism for the oncogenic capacity of Notch. In this study we investigated whether Notch signaling is involved in the tight interactions between neoplastic plasma cells and their bone marrow microenvironment, which are essential for tumor cell growth in multiple myeloma (MM). Here we demonstrate that Notch receptors and their ligand Jagged1 are highly expressed in cultured and primary MM cells, whereas nonneoplastic counterparts show low to undetectable levels of Notch. Functional data indicate that ligand-induced Notch signaling is a growth factor for MM cells and suggest that these interactions contribute to myelomagenesis in vivo.
Keywords:B-Lymphocytes, Bone Marrow Cells, Calcium-Binding Proteins, Cell Communication, Cell Division, Cell Surface Receptors, Cultured Cells, Intercellular Signaling Peptides and Proteins, Membrane Proteins, Multiple Myeloma, Proteins, Notch Receptors, Notch1 Receptor, Notch2 Receptor, Signal Transduction, Transcription Factors, Tumor Cell Line
Publisher:American Society of Hematology
Page Range:3511-3515
Date:1 January 2004
Official Publication:https://doi.org/10.1182/blood-2003-07-2254
PubMed:View item in PubMed

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