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The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity

Item Type:Review
Title:The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity
Creators Name:Mueller, G. and Hoepken, U.E. and Lipp, M.
Abstract:The development of secondary lymphoid organs is a complex process dependent on a coordinated interaction of cells of hematopoietic and non-hematopoietic origin. In this context, chemokines and cytokines belonging to the rumor necrosis fictor (TNF)/lymphotoxin (LT) family are critical signaling molecules during the initial steps of lymph node and Peyer's patch organogenesis. Homeostatic chemokines, such as CXCL13, CCL21, and CCL19, as well as their corresponding receptors, CXCR5 and CCR7, have now been shown to closely cooperate in the development of lymphoid organs and the maintenance of lymphoid tissue microarchitecture. We summarize recent data on the function of CXCR5 and CCR7 and their intricate connection to the TNF/LT system in order to refine the current model of lymphoid organ development.
Keywords:Chemokine Receptors, Cytokine Receptors, Immunity, Lymph Nodes, Peyers Patches, Spleen, Animals
Source:Immunological Reviews
ISSN:0105-2896
Publisher:Blackwell Munksgaard (Denmark)
Volume:195
Number:1
Page Range:117-135
Date:October 2003
Official Publication:https://doi.org/10.1034/j.1600-065X.2003.00073.x
PubMed:View item in PubMed

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