Reprogramming of stroma-derived chemokine networks drives the loss of tissue organization in nodal B cell lymphoma

Czernilofsky, Felix; Mathioudaki, Anna; Jopp-Saile, Lea; Lutz, Raphael; Vonficht, Dominik; Wang, Xi; Schniederjohann, Christina; Voehringer, Harald; Roider, Tobias; Baertsch, Marc-Andrea; Rodemer, Claus; Löffler-Wirth, Henry; Grau, Michael; Fitzgerald, Donnacha; Mammen, Johannes; Kosla, Jan; Liebers, Nora; Bruch, Peter-Martin; Ordoñez-Rueda, Diana; Brobeil, Alexander; Mechtersheimer, Gunhild; Pabst, Caroline; Müller-Tidow, Carsten; Trumpp, Andreas; Seifert, Marc; Neumann, Frank; Heikenwälder, Mathias; Benes, Vladimir; Huber, Wolfgang; Distler, Jörg; Lenz, Georg; Binder, Hans; Siebert, Reiner; Nolan, Garry P.; Gerstung, Moritz; Zaugg, Judith B.; Hübschmann, Daniel; Haas, Simon; Dietrich, Sascha

Reprogramming of stroma-derived chemokine networks drives the loss of tissue organization in nodal B cell lymphoma

Tools

Preview	PDF (Publisher's Version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 35MB
	Other (Supplementary Information incl. Source Data) 98MB

Item Type:	Article
Title:	Reprogramming of stroma-derived chemokine networks drives the loss of tissue organization in nodal B cell lymphoma
Creators Name:	Czernilofsky, Felix, Mathioudaki, Anna, Jopp-Saile, Lea, Lutz, Raphael, Vonficht, Dominik, Wang, Xi, Schniederjohann, Christina, Voehringer, Harald, Roider, Tobias, Baertsch, Marc-Andrea, Rodemer, Claus, Löffler-Wirth, Henry, Grau, Michael, Fitzgerald, Donnacha, Mammen, Johannes, Kosla, Jan, Liebers, Nora, Bruch, Peter-Martin, Ordoñez-Rueda, Diana, Brobeil, Alexander, Mechtersheimer, Gunhild, Pabst, Caroline, Müller-Tidow, Carsten, Trumpp, Andreas, Seifert, Marc, Neumann, Frank, Heikenwälder, Mathias, Benes, Vladimir, Huber, Wolfgang, Distler, Jörg, Lenz, Georg, Binder, Hans, Siebert, Reiner, Nolan, Garry P., Gerstung, Moritz, Zaugg, Judith B., Hübschmann, Daniel, Haas, Simon and Dietrich, Sascha
Abstract:	Lymph node (LN) function requires the organization of cells into higher-order spatial units. However, the principles governing LN architecture in health and disease remain poorly understood. Here, we used single-cell and spatial mapping to investigate the mechanisms directing immune cell organization in human LNs and its disruption in architecturally distinct lymphoma entities: indolent follicular lymphoma (FL) and aggressive diffuse large B cell lymphoma (DLBCL). Our data substantiate the central role of LN-resident stromal cells in chemokine-driven lymphocyte zonation and reveal an inflammatory feedback loop fueled by tumor-reactive T cells that triggers stromal remodeling, progressive loss of homeostatic chemokine gradients, and tissue disorganization from a non-malignant state to FL and DLBCL. Loss of homeostatic chemokines was associated with adverse patient survival, identifying the underlying architectural rearrangement as a key event during lymphomagenesis. Collectively, our results highlight the principles of LN organization and suggest how lymphoma-induced microenvironmental reprogramming drives the loss of tissue organization.
Source:	Nature Cancer
ISSN:	2662-1347
Publisher:	Springer Nature
Date:	25 March 2026
Official Publication:	https://doi.org/10.1038/s43018-026-01136-z
PubMed:	View item in PubMed
Related to:	URL URL Type https://doi.org/10.5281/zenodo.18474620 External Dataset https://edoc.mdc-berlin.de/26335/ Dataset https://edoc.mdc-berlin.de/26336/ Dataset https://www.ebi.ac.uk/biostudies/bioimages/studies/S-BIAD565 External Dataset https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE252608 External Dataset https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE252455 External Dataset https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22470 External Dataset https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE48184 External Dataset https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE43677 External Dataset https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE103944 External Dataset https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE10846 External Dataset https://ega-archive.org/studies/EGAS00001002606 External Dataset https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE98588 External Dataset https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001444 External Dataset https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000178 External Dataset https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001184 External Dataset

Repository Staff Only: item control page

Download Statistics

Downloads

Downloads per month over past year