Clonally expanded effector CD4+ cytotoxic T lymphocytes are associated with severe neurological adverse events after immune checkpoint inhibitor therapy (human)

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Title:	Clonally expanded effector CD4+ cytotoxic T lymphocytes are associated with severe neurological adverse events after immune checkpoint inhibitor therapy (human)
Abstract:	Immune checkpoint inhibitor (ICI) therapies present a pillar of modern cancer therapy but can cause severe and potentially fatal neurological immune-related adverse events (n-irAEs). Here, we performed single-cell RNA sequencing and T cell receptor profiling of PBMCs of a cohort of 17 cancer patients receiving ICI therapy. Our data suggest alterations in regulatory T cell frequencies and B cell states, and a significant enrichment of clonally expanded CD4+ cytotoxic T lymphocytes (CD4+ CTLs) with an effector gene expression profile in n-irAE patients. Overall design: 5'scRNAseq and TCR-seq analysis of PBMCs from cancer patients with or without neurological immune adverse events (n-irAEs), before or after immume checkpoint inhibition therapy ************************************************************* Submitter states that missing raw data are being made available for controlled access in EGA. *************************************************************
Source:	BioProject
Publisher:	National Center for Biotechnology Information (NCBI)
Date:	26 September 2024
External Fulltext:	View full text on external repository or document server
Related to:	URL URL Type https://edoc.mdc-berlin.de/26203/ Dataset https://edoc.mdc-berlin.de/25869/ Publication

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