![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (Original Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
10MB |
![[thumbnail of Supplementary Information]](https://edoc.mdc-berlin.de/style/images/fileicons/other.png) |
Other (Supplementary Information)
247kB |
| Item Type: | Article |
|---|---|
| Title: | Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models |
| Creators: |
Schoof, Melanie  ORCID: https://orcid.org/0000-0002-1373-8130, Zheng, Tuyu ORCID: https://orcid.org/0000-0003-3385-7353, Sill, Martin ORCID: https://orcid.org/0000-0001-7616-7665, Imle, Roland ORCID: https://orcid.org/0000-0001-9564-6952, Cais, Alessia, Altendorf, Lea, Fürst, Alicia, Hofmann, Nina, Ernst, Kati ORCID: https://orcid.org/0000-0002-8555-5907, Vonficht, Dominik, Chan, Kenneth Chun-Ho, Holland-Letz, Tim, Postlmayr, Andreas, Shiraishi, Ryo, Wang, Wanchen, Morcavallo, Alaide, Spohn, Michael ORCID: https://orcid.org/0000-0001-9160-4157, Göbel, Carolin ORCID: https://orcid.org/0000-0002-7345-2089, Niesen, Judith, Peter, Levke-Sophie ORCID: https://orcid.org/0009-0005-7283-9061, Bourdeaut, Franck ORCID: https://orcid.org/0000-0001-9489-6781, Han, Zhi-Yan, Pei, Yanxin, Murad, Najiba, Swartling, Fredrik J. ORCID: https://orcid.org/0000-0002-8460-4367, Taylor, Jessica ORCID: https://orcid.org/0000-0001-8565-8589, Yadav, Monika, Gibson, Garrett R., Gilbertson, Richard J. ORCID: https://orcid.org/0000-0001-7539-9472, Dottermusch, Matthias, Roy, Rajanya, Kerl, Kornelius ORCID: https://orcid.org/0000-0002-5676-8102, Glass, Rainer, Cheng, Jiying, Horstmann, Martin A., Wolters-Eisfeld, Gerrit ORCID: https://orcid.org/0000-0002-2984-6515, Zhao, Haotian ORCID: https://orcid.org/0000-0003-2315-8452, Sturm, Dominik, Yadav, Viveka Nand, Chesler, Louis ORCID: https://orcid.org/0000-0001-7842-2068, Haas, Simon ORCID: https://orcid.org/0000-0001-9227-2051, Weiss, William A., Northcott, Paul A ORCID: https://orcid.org/0000-0002-1220-5252, Kutscher, Lena M. ORCID: https://orcid.org/0000-0002-1130-4582, Guerreiro Stucklin, Ana ORCID: https://orcid.org/0000-0003-3136-9241, Ayrault, Olivier ORCID: https://orcid.org/0000-0002-7942-6674, Neumann, Julia E. ORCID: https://orcid.org/0000-0002-1162-8771, Kawauchi, Daisuke, Jones, David T.W. ORCID: https://orcid.org/0000-0002-2036-5141, Pajtler, Kristian, Banito, Ana ORCID: https://orcid.org/0000-0003-2188-0003, Pfister, Stefan M. ORCID: https://orcid.org/0000-0002-5447-5322, Schüller, Ulrich ORCID: https://orcid.org/0000-0002-8731-1121 and Zuckermann, Marc ORCID: https://orcid.org/0000-0003-0148-3289
|
| Abstract: | Copy number alterations (CNAs) are hallmarks of cancer, yet investigation of their oncogenic role has been hindered by technical limitations and missing model systems. Here we generated a genome-wide DNA methylation and CNA atlas of 106 genetic mouse models across 31 pediatric tumor types, including 18 new models for pediatric glioma. We demonstrated their epigenetic resemblance to human disease counterparts and identified entity-specific patterns of immune infiltration. We discovered that mouse tumors harbor highly recurrent CNA signatures that occur distinctly based on the tumor subgroup and driving oncogene and showed that these CNAs share syntenic regions with the matching human tumor types, thereby revealing a conserved but previously underappreciated role in subgroup-specific tumorigenesis that can be analyzed using the presented models. Our study provides insights into globally available mouse models for pediatric solid cancers and enables access to functional CNA interrogation, with the potential to unlock new translational targets in pediatric cancers. |
| Keywords: | Animal Disease Models, DNA Copy Number Variations, DNA Methylation, Epigenome, Genetic Epigenesis, Neoplasms, Neoplastic Gene Expression Regulation, Animals, Mice |
| Source: | Nature Genetics |
| ISSN: | 1061-4036 |
| Publisher: | Nature Publishing Group |
| Volume: | 58 |
| Number: | 1 |
| Page Range: | 143-156 |
| Date: | January 2026 |
| Official Publication: | https://doi.org/10.1038/s41588-025-02419-4 |
| PubMed: | View item in PubMed |
| Related to: |
Repository Staff Only: item control page
