Metabolic inflammation, brain age and cognitive functioning in short- and long-term clinical weight loss trials

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Item Type:	Dataset
Title:	Metabolic inflammation, brain age and cognitive functioning in short- and long-term clinical weight loss trials
Creators Name:	Maurer, Lukas and Weygandt, Martin
Abstract:	This repository contains the dataset and analysis code accompanying the manuscript: “Metabolic inflammation, brain age and cognitive functioning in short- and long-term clinical weight loss trials.” The study investigates the relationship between metabolic inflammation, weight change, and brain ageing using multimodal data (clinical, hormonal, and MRI-based brain age metrics) collected in two longitudinal, randomized weight loss trials. Data included here comprise: Aggregated clinical and biochemical variables (BMI, insulin sensitivity, leptin, fetuin-B, CRP). Brain-predicted age difference (BPAD) metrics derived from structural and diffusion MRI. Summary statistics from cognitive assessments. The accompanying MATLAB scripts reproduce the main statistical analyses and figures presented in the paper.
Source:	Zenodo
Publisher:	CERN
Date:	6 November 2025
Official Publication:	https://doi.org/10.5281/zenodo.17540341
Related to:	URL URL Type https://edoc.mdc-berlin.de/25960/ Publication https://codemeta.github.io/terms/#programmingLanguage Software

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