ACE2/Angiotensin-(1-7)/Mas and the brain

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Item Type:	Article
Title:	ACE2/Angiotensin-(1-7)/Mas and the brain
Creators Name:	Campagnole-Santos, M.J., Fontes, M.A.P., Verano-Braga, T., Haibara, A.S., Bader, M. and Santos, R.A.S.
Abstract:	It is well known that the renin-angiotensin system (RAS) plays a key role in regulating blood pressure and hydroelectrolyte balance. In addition to angiotensin (Ang) II, Ang-(1-7) has emerged as an important component of this system. Here we review evidence regarding the presence and actions of ACE2/Ang-(1-7)/Mas receptor pathway within the central nervous system, where the RAS possesses a crucial role in controlling cardiovascular, metabolic and stress-coping behavior functions. The involvement of this non-canonical RAS pathway in the brain mechanisms related to hypertension will also be discussed.
Keywords:	Angiotensin, Autonomic Regulation, Stroke, Stress and Anxiety, Baroreflex, Chemoreflex
Source:	Brain Research
ISSN:	0006-8993
Publisher:	Elsevier
Volume:	1863
Page Range:	149739
Date:	15 September 2025
Official Publication:	https://doi.org/10.1016/j.brainres.2025.149739
PubMed:	View item in PubMed

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