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| Item Type: | Article |
|---|---|
| Title: | Karyopherin α2 is a maternal effect gene required for early embryonic development and female fertility in mice |
| Creators Name: | Rother, F. and Depping, R. and Popova, E. and Huegel, S. and Heiler, A. and Hartmann, E. and Bader, M. |
| Abstract: | The nuclear transport of proteins plays an important role in mediating the transition from egg to embryo and distinct karyopherins have been implicated in this process. Here, we studied the impact of KPNA2 deficiency on preimplantation embryo development in mice. Loss of KPNA2 results in complete arrest at the 2cell stage and embryos exhibit the inability to activate their embryonic genome as well as a severely disturbed nuclear translocation of Nucleoplasmin 2. Our findings define KPNA2 as a new maternal effect gene. |
| Keywords: | Female Fertility, Importin, Karyopherin, Preimplantation Development, Animals, Mice |
| Source: | FASEB Journal |
| ISSN: | 0892-6638 |
| Publisher: | Federation of American Societies for Experimental Biology |
| Volume: | 38 |
| Number: | 8 |
| Page Range: | e23623 |
| Date: | 30 April 2024 |
| Official Publication: | https://doi.org/10.1096/fj.202301572rr |
| PubMed: | View item in PubMed |
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