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Angiotensin-(1-7) mediated calcium signalling by MAS

Item Type:Article
Title:Angiotensin-(1-7) mediated calcium signalling by MAS
Creators Name:Sureshkumar, P. and Souza dos Santos, R.A. and Alenina, N. and Mergler, S. and Bader, M.
Abstract:The G protein-coupled receptor, MAS, is the receptor of the endogenous ligand, Angiotensin (Ang)-(1-7). It is a promising drug target since the Ang-(1-7)/MAS axis is protective in the cardiovascular system. Therefore, a characterization of MAS signalling is important for developing novel therapeutics for cardiovascular diseases. In this paper, we show that Ang-(1-7) increases intracellular calcium in transiently MAS-transfected HEK293 cells. The calcium influx induced by the activation of MAS is dependent on plasma membrane Ca(2+) channels, phospholipase C, and protein kinase C. Specifically, we could demonstrate that MAS employs non-selective, transient receptor potential channels (TRPs) for calcium entry.
Keywords:Angiotensin, Calcium, MAS, Trp Channel
Page Range:171010
Date:July 2023
Official Publication:https://doi.org/10.1016/j.peptides.2023.171010
PubMed:View item in PubMed

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