Single-cell multi-omics allows functional characterization of structural variants

Item Type:	Editorial
Title:	Single-cell multi-omics allows functional characterization of structural variants
Creators Name:	Korbel, J.O. and Sanders, A.D.
Abstract:	We developed a computational method based on Strand-seq that combines nucleosome occupancy and structural variation analysis in single cells to identify the functional effects of somatic structural variants in leukemia. The method revealed the molecular consequences of somatic driver mutations and informed specific therapeutic targeting of a chromothriptic leukemic subclone.
Keywords:	Genome-Wide Association Study, Genomics, Multiomics
Source:	Nature Biotechnology
ISSN:	1087-0156
Publisher:	Nature Publishing Group
Date:	24 November 2022
Official Publication:	https://doi.org/10.1038/s41587-022-01552-3
PubMed:	View item in PubMed

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