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Disease- and sex-specific differences in patients with heart valve disease: a proteome study

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Item Type:Article
Title:Disease- and sex-specific differences in patients with heart valve disease: a proteome study
Creators Name:Nordmeyer, S. and Kraus, M. and Ziehm, M. and Kirchner, M. and Schafstedde, M. and Kelm, M. and Niquet, S. and Stephen, M.M. and Baczko, I. and Knosalla, C. and Schapranow, M.P. and Dittmar, G. and Gotthardt, M. and Falcke, M. and Regitz-Zagrosek, V. and Kuehne, T. and Mertins, P.
Abstract:Pressure overload in patients with aortic valve stenosis and volume overload in mitral valve regurgitation trigger specific forms of cardiac remodeling; however, little is known about similarities and differences in myocardial proteome regulation. We performed proteome profiling of 75 human left ventricular myocardial biopsies (aortic stenosis = 41, mitral regurgitation = 17, and controls = 17) using high-resolution tandem mass spectrometry next to clinical and hemodynamic parameter acquisition. In patients of both disease groups, proteins related to ECM and cytoskeleton were more abundant, whereas those related to energy metabolism and proteostasis were less abundant compared with controls. In addition, disease group-specific and sex-specific differences have been observed. Male patients with aortic stenosis showed more proteins related to fibrosis and less to energy metabolism, whereas female patients showed strong reduction in proteostasis-related proteins. Clinical imaging was in line with proteomic findings, showing elevation of fibrosis in both patient groups and sex differences. Disease- and sex-specific proteomic profiles provide insight into cardiac remodeling in patients with heart valve disease and might help improve the understanding of molecular mechanisms and the development of individualized treatment strategies.
Keywords:Aortic Valve Stenosis, Fibrosis, Heart Valve Diseases, Mitral Valve Insufficiency, Proteome, Proteomics, Sex Characteristics, Ventricular Remodeling
Source:Life Science Alliance
Publisher:Life Science Alliance
Page Range:e202201411
Date:March 2023
Official Publication:https://doi.org/10.26508/lsa.202201411
PubMed:View item in PubMed

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