Helmholtz Gemeinschaft


Molecular identity of proprioceptor subtypes innervating different muscle groups in mice

PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
[img] Other (Supplementary Information)

Item Type:Article
Title:Molecular identity of proprioceptor subtypes innervating different muscle groups in mice
Creators Name:Dietrich, S. and Company, C. and Song, K. and Lowenstein, E.D. and Riedel, L. and Birchmeier, C. and Gargiulo, G. and Zampieri, N.
Abstract:The precise execution of coordinated movements depends on proprioception, the sense of body position in space. However, the molecular underpinnings of proprioceptive neuron subtype identities are not fully understood. Here we used a single-cell transcriptomic approach to define mouse proprioceptor subtypes according to the identity of the muscle they innervate. We identified and validated molecular signatures associated with proprioceptors innervating back (Tox, Epha3), abdominal (C1ql2), and hindlimb (Gabrg1, Efna5) muscles. We also found that proprioceptor muscle identity precedes acquisition of receptor character and comprise programs controlling wiring specificity. These findings indicate that muscle-type identity is a fundamental aspect of proprioceptor subtype differentiation that is acquired during early development and includes molecular programs involved in the control of muscle target specificity.
Keywords:Muscles, Proprioception, Sensory Receptor Cells, Animals, Mice
Source:Nature Communications
Publisher:Nature Publishing Group
Page Range:6867
Date:11 November 2022
Official Publication:https://doi.org/10.1038/s41467-022-34589-8
PubMed:View item in PubMed

Repository Staff Only: item control page


Downloads per month over past year

Open Access
MDC Library